Probably, these conserved TRs had avoided any current TR unit changes, using a unit configuration conserved deep in to the eukaryotic tree. Thus, the TR duplications that had lead to the original expansion of your TR need to be ancient. Certainly, 52 TRs had been conserved even involving human and yeast, amounting to 13 of all human TRs that have a detectable ortholog in yeast. These ancient, ver